Thalamic functional connectivity and its association with behavioral performance in older age.

ABSTRACT: Introduction:Despite the thalamus' dense connectivity with both cortical and subcortical structures, few studies have specifically investigated how thalamic connectivity changes with age and how such changes are associated with behavior. This study investigated the effect of age on thalamo-cortical and thalamo-hippocampal functional connectivity (FC) and the association between thalamic FC and visual-spatial memory and reaction time (RT) performance in older adults. Methods:Resting-state functional magnetic resonance images were obtained from younger (n = 20) and older (n = 20) adults. A seed-based approach was used to assess the FC between the thalamus and (1) sensory resting-state networks; (2) the hippocampus. Participants also completed visual-spatial memory and RT tasks, from the Camb

SUBMITTER: Goldstone A 

PROVIDER: S-EPMC5893345 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature