Functional Anti-TIGIT Antibodies Regulate Development of Autoimmunity and Antitumor Immunity.

ABSTRACT: Coinhibitory receptors, such as CTLA-4 and PD-1, play a critical role in maintaining immune homeostasis by dampening T cell responses. Recently, they have gained attention as therapeutic targets in chronic disease settings where their dysregulated expression contributes to suppressed immune responses. The novel coinhibitory receptor TIGIT (T cell Ig and ITIM domain) has been shown to play an important role in modulating immune responses in the context of autoimmunity and cancer. However, the molecular mechanisms by which TIGIT modulates immune responses are still insufficiently understood. We have generated a panel of monoclonal anti-mouse TIGIT Abs that show functional properties in mice in vivo and can serve as important tools to study the underlying mechanisms of TIGIT function. We have

SUBMITTER: Dixon KO 

PROVIDER: S-EPMC5893394 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature