A 24-year prospective study of dietary α-linolenic acid and lethal prostate cancer.

ABSTRACT: Several meta-analyses have attempted to determine the relationships between intake of α-linolenic acid (ALA) and prostate cancer, but results were inconclusive. 47,885 men aged 40-75 years without prior cancer in the Health Professionals Follow-Up Study were prospectively followed from 1986 to 2010. Intake of ALA was determined from validated food frequency questionnaires every 4 years. We used multivariate Cox proportional hazards models to estimate hazard ratios (HR) with 95% confidence intervals (CIs) for lethal prostate cancer (distant metastasis or prostate cancer death). 386 lethal prostate cancers were diagnosed in the pre-PSA era (before February, 1994) and 403 cancers in the PSA era. Intake of ALA was associated with increased risk of lethal prostate cancer in the pre-PSA era (com

SUBMITTER: Wu J 

PROVIDER: S-EPMC5893397 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature