Single nucleotide polymorphisms might influence chemotherapy induced nausea in women with breast cancer.

ABSTRACT:

Background

Women receiving FEC (5 fluorouracil, epirubicin and cyclophosphamide) chemotherapy (CT) for breast cancer (BC) often experience side effects such as nausea and vomiting. Individual variations of side effects occur in patients despite similar cancer therapy. The purpose of this study was to investigate a possible genetic background as a predictor for individual variations in nausea induced by CT.

Methods

114 women were included in the study. All women received adjuvant CT for BC. Self-reported nausea and vomiting was recorded in a structured diary over ten days following treatment. Blood samples were collected before the treatment and used for the detection of 48 single nucleotide polymorphisms (SNPs) in 43 genes. SNPs from each individual woman were analyzed for t

SUBMITTER: Oliva D 

PROVIDER: S-EPMC5893496 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature