Glut-1 expression in small cervical biopsies is prognostic in cervical cancers treated with chemoradiation.

ABSTRACT:

Background/purpose

Chemoradiation (CRT) is standard therapy for locally advanced cervical cancer (LACC). However, there is a lack of biomarkers to identify patients at high relapse-risk. We examine metabolic (glucose transporter-1 [Glut-1]), hypoxic (hypoxia inducible factor [HIF-1α]; carbonic anhydrase [CA-9]) and proliferative (Ki-67) markers for prognostic utility in LACC.

Materials/methods

60 LACC patients treated with CRT had pre-treatment biopsies. Immunohistochemistry was performed for Glut-1, HIF-1a and CA-9, to generate a histoscore from intensity and percentage staining; and Ki-67 scored by percentage of positive cells. For each biomarker, treatment response and survival was compared between low and high-staining groups by logrank testing and multivariate analyses.

SUBMITTER: Kanjanapan Y 

PROVIDER: S-EPMC5893520 | biostudies-literature | 2017 Feb

REPOSITORIES: biostudies-literature