Gestational exposure to metformin programs improved glucose tolerance and insulin secretion in adult male mouse offspring.

ABSTRACT: Pancreatic β-cells are exquisitely sensitive to developmental nutrient stressors, and alterations in nutrient sensing pathways may underlie changes observed in these models. Here we developed a mouse model of in utero exposure to the anti-diabetic agent metformin. We have previously shown that this exposure increases offspring pancreatic β-cell mass at birth. We hypothesized that adult offspring would have improved metabolic parameters as a long-term outcome of metformin exposure. Virgin dams were given 5 mg/mL metformin in their water from E0.5 to delivery at E18.5. Body weight, glucose tolerance, insulin tolerance and glucose stimulated insulin secretion were analyzed in the offspring. When male offspring of dams given metformin during gestation were tested as adults they had improved gl

SUBMITTER: Gregg BE 

PROVIDER: S-EPMC5893596 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature