Calorie restriction is the most reasonable anti-ageing intervention: a meta-analysis of survival curves.

ABSTRACT: Despite technological advances, the survival records from longevity experiments remain the most indispensable tool in ageing-related research. A variety of interventions, including medications, genetic manipulations and calorie restriction (CR), have been demonstrated to extend the lifespan of several species. Surprisingly, few systematic studies have investigated the differences among these anti-ageing strategies using survival data. Here, we conduct a comprehensive and comparative meta-analysis of numerous published studies on Caenorhabditis elegans and Drosophila. We found that CR and genetic manipulations are generally more effective than medications at extending the total lifespan in both models, and CR can improve the ageing pattern of C. elegans. We further analysed the survival var

SUBMITTER: Liang Y 

PROVIDER: S-EPMC5893623 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature