Human Vγ9Vδ2-T Cells Synergize CD4⁺ T Follicular Helper Cells to Produce Influenza Virus-Specific Antibody.

ABSTRACT: Human Vγ9Vδ2-T cells recognize nonpeptidic antigens and exert effector functions against microorganisms and tumors, but little is known about their roles in humoral immune response against influenza virus infection. Herein, in the coculture of autologous human B cells, dendritic cells and/or naïve CD4 T cells, and Vγ9Vδ2-T cells, we demonstrated that Vγ9Vδ2-T cells could facilitate H9N2 influenza virus-specific IgG and IgM productions in a CD4 T cell-dependent manner. Vγ9Vδ2-T cells promoted the differentiation of CXCR5⁺PD1⁺CD4⁺ T follicular helper (Tfh) cells, CD19⁺IgD^-CD38⁺⁺ plasma cells (PCs), and drove B cell proliferation as well as immunoglobulin class switching. Interestingly, Vγ9Vδ2-T cells acquired Tfh-associated mo

SUBMITTER: Chen Q 

PROVIDER: S-EPMC5893649 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature