Clinical and Molecular Features of Thiazide-Induced Hyponatremia.

ABSTRACT:

Purpose of review

Hypertension affects more than 30% of the world's adult population and thiazide (and thiazide-like) diuretics are amongst the most widely used, effective, and least costly treatments available, with all-cause mortality benefits equivalent to angiotensin-converting enzyme inhibitors or calcium channel antagonists. A minority of patients develop thiazide-induced hyponatremia (TIH) and this is largely unpredictable at the point of thiazide prescription. In some cases, TIH can cause debilitating symptoms and require hospital admission. Although TIH affects only a minority of patients exposed to thiazides, the high prevalence of hypertension leads to TIH being the most common cause of drug-induced hyponatremia requiring hospital admission in the UK. This review examine

SUBMITTER: Nadal J 

PROVIDER: S-EPMC5893690 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature