Neural Correlates of Semantic Inhibition in Relation to Hypomanic Traits: An fMRI Study.

ABSTRACT:

Objectives

Language modifications are a core feature of mania, but little is known about the semantic mechanisms behind these disturbances. The aim of the present study was thus to identify deficits in semantic inhibition and their respective neural activation patterns in a sample of individuals assessed for hypomanic personality traits.

Methods

Thirty-six young adults with no neurological or psychiatric diagnoses were assessed for hypomanic personality traits with the Hypomanic Personality Scale (HPS) and underwent an fMRI task of semantic ambiguity resolution.

Results

Regression analyses revealed a positive association between the HPS score and activity in the left superior frontal gyrus, left inferior parietal lobule, and anterior cingulate gyrus during semantic am

SUBMITTER: Raucher-Chene D 

PROVIDER: S-EPMC5893717 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature