Distinct and Modular Organization of Protein Interacting Sites in Long Non-coding RNAs.

ABSTRACT: Background: Long non-coding RNAs (lncRNAs), are being reported to be extensively involved in diverse regulatory roles and have exhibited numerous disease associations. LncRNAs modulate their function through interaction with other biomolecules in the cell including DNA, RNA, and proteins. The availability of genome-scale experimental datasets of RNA binding proteins (RBP) motivated us to understand the role of lncRNAs in terms of its interactions with these proteins. In the current report, we demonstrate a comprehensive study of interactions between RBP and lncRNAs at a transcriptome scale through extensive analysis of the crosslinking and immunoprecipitation (CLIP) experimental datasets available for 70 RNA binding proteins. Results: Our analysis suggests that density of int

SUBMITTER: Jalali S 

PROVIDER: S-EPMC5893854 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature