A novel healthy blood pressure phenotype in the Long Life Family Study.

ABSTRACT:

Background

Hypertension tends to run in families and has both genetic and environmental determinants. We assessed the hypothesis that a novel healthy blood pressure (BP) phenotype is also familial and sought to identify its associated factors.

Methods

We developed a healthy BP phenotype in the Long Life Family Study, a cohort of two-generation families selected for longevity. Participants from the offspring generation (n = 2211, ages 32-88) were classified as having healthy BP if their age-adjusted and sex-adjusted SBP z-score was between -1.5 and -0.5. Offspring on antihypertensive medications were classified as not having healthy BP. Families with at least two offspring (n = 419 families) were defined as meeting the healthy BP phenotype if at least two and at least 50% of

SUBMITTER: Marron MM 

PROVIDER: S-EPMC5893936 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature