Trends in the contemporary incidence of colorectal cancer and patient characteristics in the United Kingdom: a population-based cohort study using The Health Improvement Network.

ABSTRACT: BACKGROUND:Cancer registry data show that survival of colorectal cancer (CRC) in the United Kingdom is poor compared with other European countries and the United States, yet these data sources lack information on patient comorbidities and medication use, which could help explain these differences. METHODS:Among individuals aged 40-89 years in The Health Improvement Network (2000-2014), we identified first ever cases of CRC and calculated incidence rates with 95% confidence intervals (CIs). For CRC cases and non-cases in two separate calendar years (2002 and 2014), we evaluated patient demographics, lifestyle factors, comorbidities and medication use and bowel screening. RESULTS:The incidence of CRC remained relatively constant across the study period; incidence rates per 10,000 person-year

SUBMITTER: Soriano LC 

PROVIDER: S-EPMC5894203 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature