Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus.

ABSTRACT:

Background

African Americans with systemic lupus erythematosus (SLE) have increased renal disease compared to Caucasians, but differences in other comorbidities have not been well-described. We used an electronic health record (EHR) technique to test for differences in comorbidities in African Americans compared to Caucasians with SLE.

Methods

We used a de-identified EHR with 2.8 million subjects to identify SLE cases using a validated algorithm. We performed phenome-wide association studies (PheWAS) comparing African American to Caucasian SLE cases and African American SLE cases to matched non-SLE controls. Controls were age, sex, and race matched to SLE cases. For multiple testing, a false discovery rate (FDR) p value of 0.05 was used.

Results

We identified 270 Afri

SUBMITTER: Barnado A 

PROVIDER: S-EPMC5894248 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature