Whole-Blood Gene Expression in Pulmonary Nontuberculous Mycobacterial Infection.

ABSTRACT: The factors predisposing toward the development of pulmonary nontuberculous mycobacterial (pNTM) disease and influencing disease progression remain unclear. Impaired immune responses have been reported in individuals with pNTM disease, but data are limited and inconsistent. In this study, we sought to use gene expression profiling to examine the host response to pNTM disease. Microarray analysis of whole-blood gene expression was performed on 25 subjects with pNTM disease and 27 uninfected control subjects with respiratory disease. Gene expression results were compared with phenotypic variables and survival data. Compared with uninfected control subjects, pNTM disease was associated with downregulation of 213 transcripts enriched for terms related to T cell signaling, including IFNG. Reduc

SUBMITTER: Cowman SA 

PROVIDER: S-EPMC5894497 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature