Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study.

ABSTRACT:

Purpose

Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry study (LG Growth Study) was initiated to assess the safety and effectiveness of four types of rhGH products in real-life settings.

Methods

A total of 4,000 children will be registered and prospectively followed up at 6-month intervals until 2 years after epiphyseal closure to collect data on treatment and adverse events, with primary interest in malignancies and growth outcomes.

Results

As of 22 March 2017, approximately 50% (2,024) of the target number of patients have been included in the analysis set: growth hormone deficiency, 1,297 (64.1%); idiopathic short stature, 31

SUBMITTER: Chung S 

PROVIDER: S-EPMC5894560 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature