FGF23 modulates the effects of erythropoietin on gene expression in renal epithelial cells.

ABSTRACT:

Background

FGF23 plays an important role in calcium-phosphorus metabolism. Other roles of FGF23 have recently been reported, such as commitment to myocardium enlargement and immunological roles in the spleen. In this study, we aimed to identify the roles of FGF23 in the kidneys other than calcium-phosphorus metabolism.

Methods

DNA microarrays and bioinformatics tools were used to analyze gene expression in mIMCD3 mouse renal tubule cells following treatment with FGF23, erythropoietin and/or an inhibitor of ERK.

Results

Three protein-coding genes were upregulated and 12 were downregulated in response to FGF23. Following bioinformatics analysis of these genes, PPARγ and STAT3 were identified as candidate transcript factors for mediating their upregulation, and STAT1 as

SUBMITTER: Yashiro M 

PROVIDER: S-EPMC5894721 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature