High-throughput dietary exposure predictions for chemical migrants from food contact substances for use in chemical prioritization.

ABSTRACT: Under the ExpoCast program, United States Environmental Protection Agency (EPA) researchers have developed a high-throughput (HT) framework for estimating aggregate exposures to chemicals from multiple pathways to support rapid prioritization of chemicals. Here, we present methods to estimate HT exposures to chemicals migrating into food from food contact substances (FCS). These methods consisted of combining an empirical model of chemical migration with estimates of daily population food intakes derived from food diaries from the National Health and Nutrition Examination Survey (NHANES). A linear regression model for migration at equilibrium was developed by fitting available migration measurements as a function of temperature, food type (i.e., fatty, aqueous, acidic, alcoholic), initial

SUBMITTER: Biryol D 

PROVIDER: S-EPMC5894819 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature