Orbital and Medial Prefrontal Cortex Functional Connectivity of Major Depression Vulnerability and Disease.

ABSTRACT: BACKGROUND:Pathophysiology models of major depression (MD) center on the dysfunction of various cortical areas within the orbital and medial prefrontal cortex. While independent structural and functional abnormalities in these areas are consistent findings in MD, the complex interactions among them and the rest of the cortex remain largely unexplored. METHODS:We used resting-state functional magnetic resonance imaging connectivity to systematically map alterations in the communication between orbital and medial prefrontal cortex fields and the rest of the brain in MD. Functional connectivity (FC) maps from participants with current MD (n = 35), unaffected first-degree relatives (n = 36), and healthy control subjects (n = 38) were subjected to conjunction analyses to distinguish FC markers

SUBMITTER: Samara Z 

PROVIDER: S-EPMC5894884 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature