Superior cervical gangliectomy induces non-exudative age-related macular degeneration in mice.

ABSTRACT: Non-exudative age-related macular degeneration, a prevalent cause of blindness, is a progressive and degenerative disease characterized by alterations in Bruch's membrane, retinal pigment epithelium, and photoreceptors exclusively localized in the macula. Although experimental murine models exist, the vast majority take a long time to develop retinal alterations and, in general, these alterations are ubiquitous, with many resulting from non-eye-specific genetic manipulations; additionally, most do not always reproduce the hallmarks of human age-related macular degeneration. Choroid vessels receive sympathetic innervation from the superior cervical ganglion, which, together with the parasympathetic system, regulates blood flow into the choroid. Choroid blood flow changes have been involved

SUBMITTER: Dieguez HH 

PROVIDER: S-EPMC5894943 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature