Muscle mass, BMI, and mortality among adults in the United States: A population-based cohort study.

ABSTRACT: BACKGROUND:The level of body-mass index (BMI) associated with the lowest risk of death remains unclear. Although differences in muscle mass limit the utility of BMI as a measure of adiposity, no study has directly examined the effect of muscle mass on the BMI-mortality relationship. METHODS:Body composition was measured by dual-energy x-ray absorptiometry in 11,687 participants of the National Health and Nutrition Examination Survey 1999-2004. Low muscle mass was defined using sex-specific thresholds of the appendicular skeletal muscle mass index (ASMI). Proportional hazards models were created to model associations with all-cause mortality. RESULTS:At any level of BMI ≥22, participants with low muscle mass had higher body fat percentage (%TBF), an increased likelihood of diabetes, and hig

SUBMITTER: Abramowitz MK 

PROVIDER: S-EPMC5894968 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature