Measuring serum melatonin in postmenopausal women: Implications for epidemiologic studies and breast cancer studies.

ABSTRACT:

Background

Circulating melatonin is a good candidate biomarker for studies of circadian rhythms and circadian disruption. However, epidemiologic studies on circulating melatonin are limited because melatonin is secreted at night, yet most epidemiologic studies collect blood during the day when melatonin levels are very low, and assays are lacking that are ultrasensitive to detect low levels of melatonin reliably.

Objective

To assess the performance of a refined radioimmunoassay in measuring morning melatonin among women.

Methods

We used morning serum samples from 47 postmenopausal women ages 48-80 years without a history of breast cancer who participated in the San Francisco Bay Area Breast Cancer Study, including 19 women who had duplicate measurements. The coefficie

SUBMITTER: Chu LW 

PROVIDER: S-EPMC5895067 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature