Hepatitis C virus cure does not impact kidney function decline in HIV co-infected patients.

ABSTRACT: OBJECTIVE:To examine the impact of sustained virologic response (SVR) and illicit (injection and noninjection) drug use on kidney function among hepatitis C virus (HCV) and HIV co-infected individuals. DESIGN:Longitudinal observational cohort study of HCV-HIV co-infected patients. METHODS:Data from 1631 patients enrolled in the Canadian Co-Infection Cohort between 2003 and 2016 were analyzed. Patients who achieved SVR were matched 1 : 2 with chronically infected patients using time-dependent propensity scores. Linear regression with generalized estimating equations was used to model differences in estimated glomerular filtration rates (eGFR) between chronic HCV-infected patients and those achieving SVR. The relationship between illicit drug use and eGFR was explored in patients who achieve

SUBMITTER: Rossi C 

PROVIDER: S-EPMC5895129 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature