Association of aspartic acid repeat polymorphism in the asporin gene with osteoarthritis of knee, hip, and hand: A PRISMA-compliant meta-analysis.

ABSTRACT:

Objective

Several human studies have been conducted to explore the association between aspirin (ASPN) D-repeat polymorphisms and OA susceptibility, but these provide inconsistent results. Our primary aim is to examine whether D-repeat polymorphisms are related to OA risk.

Methods

We conducted a meta-analysis to investigate the association between ASPN D-repeat polymorphisms and OA. Electronic database was searched, including PubMed, Embase, CNKI, Ovid, and the reference lists of relevant articles published from the inception to January 24, 2018. The included studies were assessed in the following allele model: D14 allele versus others combined, D13 allele versus others combined, D15 allele versus others combined, and D14 allele versus D13 allele. Female population was also a

SUBMITTER: Zhu X 

PROVIDER: S-EPMC5895348 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature