Metabolic enzyme PFKFB4 activates transcriptional coactivator SRC-3 to drive breast cancer.

ABSTRACT: Alterations in both cell metabolism and transcriptional programs are hallmarks of cancer that sustain rapid proliferation and metastasis ¹ . However, the mechanisms that control the interaction between metabolic reprogramming and transcriptional regulation remain unclear. Here we show that the metabolic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4) regulates transcriptional reprogramming by activating the oncogenic steroid receptor coactivator-3 (SRC-3). We used a kinome-wide RNA interference-based screening method to identify potential kinases that modulate the intrinsic SRC-3 transcriptional response. PFKFB4, a regulatory enzyme that synthesizes a potent stimulator of glycolysis ² , is found to be a robust stimulator of SRC-3 that coregulate

SUBMITTER: Dasgupta S 

PROVIDER: S-EPMC5895503 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature