The morphometric co-atrophy networking of schizophrenia, autistic and obsessive spectrum disorders.

ABSTRACT: By means of a novel methodology that can statistically derive patterns of co-alterations distribution from voxel-based morphological data, this study analyzes the patterns of brain alterations of three important psychiatric spectra-that is, schizophrenia spectrum disorder (SCZD), autistic spectrum disorder (ASD), and obsessive-compulsive spectrum disorder (OCSD). Our analysis provides five important results. First, in SCZD, ASD, and OCSD brain alterations do not distribute randomly but, rather, follow network-like patterns of co-alteration. Second, the clusters of co-altered areas form a net of alterations that can be defined as morphometric co-alteration network or co-atrophy network (in the case of gray matter decreases). Third, within this network certain cerebral areas can be identifie

SUBMITTER: Cauda F 

PROVIDER: S-EPMC5895505 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature