Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.

ABSTRACT: Breast cancer remains the leading cause of cancer death in women owing to metastasis and the development of resistance to established therapies. Macrophages are the most abundant immune cells in the breast tumor microenvironment and can both inhibit and support cancer progression. Thus, gaining a better understanding of how macrophages support cancer could lead to the development of more effective therapies. In this study, we find that breast cancer-associated macrophages express high levels of insulin-like growth factors 1 and 2 (IGFs) and are the main source of IGFs within both primary and metastatic tumors. In total, 75% of breast cancer patients show activation of insulin/IGF-1 receptor signaling and this correlates with increased macrophage infiltration and advanced tumor stage. In pa

SUBMITTER: Ireland L 

PROVIDER: S-EPMC5895608 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature