Causal Pathways from Blood Pressure to Larger Qrs Amplitudes a Mendelian Randomization Study.

ABSTRACT: Abnormal QRS duration and amplitudes on the electrocardiogram are indicative of cardiac pathology and are associated with adverse outcomes. The causal nature of these associations remains uncertain and could be due to QRS abnormalities being a symptom of cardiac damage rather than a factor on the causal pathway. By performing Mendelian randomization (MR) analyses using summary statistics of genome wide association study consortia with sample sizes between 20,687 and 339,224 individuals, we aimed to determine which cardiovascular risk factors causally lead to changes in QRS duration and amplitude (Sokolow-Lyon, Cornell and 12-leadsum products). Additionally, we aimed to determine whether QRS traits have a causal relationship with mortality and longevity. We performed inverse-variance weight

SUBMITTER: Van Der Ende MY 

PROVIDER: S-EPMC5895613 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature