Nucleosomes of polyploid trophoblast giant cells mostly consist of histone variants and form a loose chromatin structure.

ABSTRACT: Trophoblast giant cells (TGCs) are one of the cell types that form the placenta and play multiple essential roles in maintaining pregnancy in rodents. TGCs have large, polyploid nuclei resulting from endoreduplication. While previous studies have shown distinct gene expression profiles of TGCs, their chromatin structure remains largely unknown. An appropriate combination of canonical and non-canonical histones, also known as histone variants, allows each cell to exert its cell type-specific functions. Here, we aimed to reveal the dynamics of histone usage and chromatin structure during the differentiation of trophoblast stem cells (TSCs) into TGCs. Although the expression of most genes encoding canonical histones was downregulated, the expression of a few genes encoding histone variants su

SUBMITTER: Hayakawa K 

PROVIDER: S-EPMC5895725 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature