How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin.

ABSTRACT: Influenza virus can escape most antibodies with single mutations. However, rare antibodies broadly neutralize many viral strains. It is unclear how easily influenza virus might escape such antibodies if there was strong pressure to do so. Here, we map all single amino-acid mutations that increase resistance to broad antibodies to H1 hemagglutinin. Our approach not only identifies antigenic mutations but also quantifies their effect sizes. All antibodies select mutations, but the effect sizes vary widely. The virus can escape a broad antibody to hemagglutinin's receptor-binding site the same way it escapes narrow strain-specific antibodies: via single mutations with huge effects. In contrast, broad antibodies to hemagglutinin's stalk only select mutations with small effects. Therefore, amon

SUBMITTER: Doud MB 

PROVIDER: S-EPMC5895760 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature