The Resistome of Low-Impacted Marine Environments Is Composed by Distant Metallo-β-Lactamases Homologs.

ABSTRACT: The worldwide dispersion and sudden emergence of new antibiotic resistance genes (ARGs) determined the need in uncovering which environment participate most as their source and reservoir. ARGs closely related to those currently found in human pathogens occur in the resistome of anthropogenic impacted environments. However, the role of pristine environment as the origin and source of ARGs remains underexplored and controversy, particularly, the marine environments represented by the oceans. Here, due to the ocean nature, we hypothesized that the resistome of this pristine/low-impacted marine environment is represented by distant ARG homologs. To test this hypothesis we performed an in silico analysis on the Global Ocean Sampling (GOS) metagenomic project dataset focusing on the metallo-β-la

SUBMITTER: Fonseca EL 

PROVIDER: S-EPMC5895761 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature