Changing patterns of human migrations shaped the global population structure of Mycobacterium tuberculosis in France.

ABSTRACT: Mycobacterium tuberculosis (Mtb) exhibits a structured phylogeographic distribution worldwide linked with human migrations. We sought to infer how the interactions between distinct human populations shape the global population structure of Mtb on a regional scale. We applied the recently described timescaled haplotypic density (THD) technique on 638 minisatellite-based Mtb genotypes from French tuberculosis patients. THD with a long-term (200 y) timescale indicated that Mtb population in France had been mostly influenced by interactions with Eastern and Southern Europe and, to a lesser extent, Northern and Middle Africa, consistent with historical migrations favored by geographic proximity or commercial exchanges with former French colonies. Restricting the timescale to 20 y, THD identifie

SUBMITTER: Barbier M 

PROVIDER: S-EPMC5895845 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature