Galectin-3 Reflects the Echocardiographic Grades of Left Ventricular Diastolic Dysfunction.

ABSTRACT:

Background

The level of Galectin-3 (Gal-3) protein purportedly reflects an ongoing cardiac fibrotic process and has been associated with ventricular remodeling, which is instrumental in the development of heart failure with preserved ejection fraction (HFpEF) syndrome. The aim of this study was to investigate the potential use of Gal-3 in improved characterization of the grades of diastolic dysfunction as defined by echocardiography.

Methods

Seventy HFpEF patients undergoing routine echocardiography were prospectively enrolled in the present monocentric study. Blood samples for measurements of Gal-3 and amino-terminal pro-brain natriuretic peptide (NT-proBNP) were collected within 24 hours pre- or post-echocardiographic examination. The classification of patients into subgro

SUBMITTER: Ansari U 

PROVIDER: S-EPMC5895859 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature