Left frontal pole theta burst stimulation decreases orbitofrontal and insula activity in cocaine users and alcohol users.

ABSTRACT:

Background

Preclinical research has demonstrated a causal relationship between medial prefrontal cortex activity and cocaine self-administration. As a step towards translating those data to a neural circuit-based intervention for patients, this study sought to determine if continuous theta burst stimulation (cTBS) to the left frontal pole (FP), would attenuate frontal-striatal activity in two substance-dependent populations.

Methods

Forty-nine substance dependent individuals (25 cocaine, 24 alcohol) completed a single-blind, sham-controlled, crossover study wherein they received 6 trains of real or sham cTBS (110% resting motor threshold, FP1) each visit. Baseline evoked BOLD signal was measured immediately before and after real and sham cTBS (interleaved TMS/BOLD imaging: s

SUBMITTER: Hanlon CA 

PROVIDER: S-EPMC5896018 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature