Multi-cohort analysis of colorectal cancer metagenome identified altered bacteria across populations and universal bacterial markers.

ABSTRACT:

Background

Alterations of gut microbiota are associated with colorectal cancer (CRC) in different populations and several bacterial species were found to contribute to the tumorigenesis. The potential use of gut microbes as markers for early diagnosis has also been reported. However, cohort specific noises may distort the structure of microbial dysbiosis in CRC and lead to inconsistent results among studies. In this regard, our study targeted at exploring changes in gut microbiota that are universal across populations at species level.

Results

Based on the combined analysis of 526 metagenomic samples from Chinese, Austrian, American, and German and French cohorts, seven CRC-enriched bacteria (Bacteroides fragilis, Fusobacterium nucleatum, Porphyromonas asaccharolytica, Parvi

SUBMITTER: Dai Z 

PROVIDER: S-EPMC5896039 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature