Preoperative metabolic tumor volume of intrahepatic cholangiocarcinoma measured by ¹⁸F-FDG-PET is associated with the KRAS mutation status and prognosis.

ABSTRACT:

Background

Surgical resection remains the mainstay of curative treatment for intrahepatic cholangiocarcinoma (ICC). Prognosis after surgery is unsatisfactory despite improvements in treatment and post-operative clinical management. Despite developments in the molecular profiling of ICC, the preoperative prediction of prognosis remains a challenge. This study aimed to identify clinical prognostic indicators by investigating the molecular profiles of ICC and evaluating the preoperative imaging data of ¹⁸F-fluorodeoxyglucose positron emission tomography (¹⁸F-FDG-PET).

Methods

A retrospective analysis was performed on 50 consecutive patients with ICC who underwent curative hepatectomy after ¹⁸F-FDG-PET examination. To evaluate the molecular profi

SUBMITTER: Ikeno Y 

PROVIDER: S-EPMC5896043 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature