A comparative genomics study of carbohydrate/glucose metabolic genes: from fish to mammals.

ABSTRACT:

Background

Glucose plays a key role as an energy source in most mammals, but its importance in fish appears to be limited that so far seemed to belong to diabetic humans only. Several laboratories worldwide have made important efforts in order to better understand this strange phenotype observed in fish. However, the mechanism of carbohydrate/glucose metabolism is astonishingly complex. Why basal glycaemia is different between fish and mammals and how carbohydrate metabolism is different amongst organisms is largely uncharted territory. The utilization of comparative systems biology with model vertebrates to explore fish metabolism has become an essential approach to unravelling hidden in vivo mechanisms.

Results

In this study, we first built a database containing 791, 593,

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC5896114 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature