TIA: algorithms for development of identity-linked SNP islands for analysis by massively parallel DNA sequencing.

ABSTRACT:

Background

Single nucleotide polymorphisms (SNPs) located within the human genome have been shown to have utility as markers of identity in the differentiation of DNA from individual contributors. Massively parallel DNA sequencing (MPS) technologies and human genome SNP databases allow for the design of suites of identity-linked target regions, amenable to sequencing in a multiplexed and massively parallel manner. Therefore, tools are needed for leveraging the genotypic information found within SNP databases for the discovery of genomic targets that can be evaluated on MPS platforms.

Results

The SNP island target identification algorithm (TIA) was developed as a user-tunable system to leverage SNP information within databases. Using data within the 1000 Genomes Project SNP d

SUBMITTER: Farris MH 

PROVIDER: S-EPMC5896139 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature