Putative human sperm Interactome: a networks study.

ABSTRACT:

Background

For over sixty years, it has been known that mammalian spermatozoa immediately after ejaculation are virtually infertile. They became able to fertilize only after they reside for long time (hours to days) within female genital tract where they complete their functional maturation, the capacitation. This process is finely regulated by the interaction with the female environment and involves, in spermatozoa, a myriad of molecules as messengers and target of signals. Since, to date, a model able to represent the molecular interaction that characterize sperm physiology does not exist, we realized the Human Sperm Interactme Network3.0 (HSIN3.0) and its main component (HSNI3.0_MC), starting from the pathway active in male germ cells.

Results

HSIN3.0 and HSIN3.0_MC are s

SUBMITTER: Ordinelli A 

PROVIDER: S-EPMC5896140 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature