Rheumatoid Arthritis and miRNAs: A Critical Review through a Functional View.

ABSTRACT: Rheumatoid arthritis (RA) is a systemic autoimmune disease with severe joint inflammation and destruction associated with an inflammatory environment. The etiology behind RA remains to be elucidated; most updated concepts include the participation of environmental, proteomic, epigenetic, and genetic factors. Epigenetic is considered the missing link to explain genetic diversification among RA patients. Within epigenetic factors participating in RA, miRNAs are defined as small noncoding molecules with a length of approximately 22 nucleotides, capable of gene expression modulation, either negatively through inhibition of translation and degradation of the mRNA or positively through increasing the translation rate. Over the last decade and due to the feasibility of the identification of miRNA

SUBMITTER: Moran-Moguel MC 

PROVIDER: S-EPMC5896204 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature