A genome-wide association study of emotion dysregulation: Evidence for interleukin 2 receptor alpha.

ABSTRACT: Emotion dysregulation has been implicated as a risk factor for many psychiatric conditions. Therefore, examining genetic risk associated with emotion dysregulation could help inform cross-disorder risk more generally. A genome-wide association study (GWAS) of emotion dysregulation using single nucleotide polymorphism (SNP) array technology was conducted in a highly traumatized, minority, urban sample (N = 2600, males = 774). Post-hoc analyses examined associations between SNPs identified in the GWAS and current depression, posttraumatic stress disorder (PTSD), and history of suicide attempt. Methylation quantitative trait loci were identified and gene set enrichment analyses were used to broadly determine biological processes involved with these SNPs. Among males, SNP rs6602398, located wi

SUBMITTER: Powers A 

PROVIDER: S-EPMC5896292 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature