Genotype × Environment Interaction in Smoking Behaviors: A Systematic Review.

ABSTRACT:

Introduction

There has been rapid growth in research exploring gene-environment interaction (G×E) contributing to smoking behaviors. Yet, no systematic review exists to date.

Methods

This article aims to review evidence on the contribution of G×E to the risk of smoking. Through a search of electronic databases (ie, Google Scholar, PubMed, ScienceDirect, and Elsevier) up until May 2014, 16 studies of G×E focused on smoking behaviors were identified. These studies were compared in terms of: research design and sample studied, measure of smoking behavior and environments used, genes explored, and G×E in relation to these factors.

Results

Thirteen of 16 studies (81.2%) found at least one significant G×E association. Wide variation in analytic methods was found across stud

SUBMITTER: Do EK 

PROVIDER: S-EPMC5896454 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature