Combination Varenicline/Bupropion Treatment Benefits Highly Dependent Smokers in an Adaptive Smoking Cessation Paradigm.

ABSTRACT:

Introduction

This study replicated and extended results of a previous trial, which found that combination varenicline/bupropion treatment increased smoking abstinence in smokers who were male, highly dependent, and who did not respond to prequit nicotine patch treatment with a >50% reduction in expired-air carbon monoxide in the first week.

Methods

One hundred and twenty-two male nicotine patch nonresponders and 52 responders were identified. Smokers in each group were randomized to receive 12 weeks of varenicline plus bupropion treatment versus varenicline plus placebo. The primary outcome was continuous smoking abstinence at weeks 8-11 after the target quit date.

Results

For smokers with a high level of dependence, judged by having a baseline Fagerstrom Test for Nic

SUBMITTER: Rose JE 

PROVIDER: S-EPMC5896474 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature