Secreted Proteins Defy the Expression Level-Evolutionary Rate Anticorrelation.

ABSTRACT: The rates of evolution of the proteins of any organism vary across orders of magnitude. A primary factor influencing rates of protein evolution is expression. A strong negative correlation between expression levels and evolutionary rates (the so-called E-R anticorrelation) has been observed in virtually all studied organisms. This effect is currently attributed to the abundance-dependent fitness costs of misfolding and unspecific protein-protein interactions, among other factors. Secreted proteins are folded in the endoplasmic reticulum, a compartment where chaperones, folding catalysts, and stringent quality control mechanisms promote their correct folding and may reduce the fitness costs of misfolding. In addition, confinement of secreted proteins to the extracellular space may reduce mi

SUBMITTER: Feyertag F 

PROVIDER: S-EPMC5896516 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature