A Genetic Epidemiological Mega Analysis of Smoking Initiation in Adolescents.

ABSTRACT:

Introduction

Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation (SI) across adolescence.

Methods

Mega-analysis of pooled genetically informative data on SI was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N = 19 313 pairs) between ages 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the United States, Europe, and Australia.

Results

Al

SUBMITTER: Maes HH 

PROVIDER: S-EPMC5896552 | biostudies-literature | 2017 Apr

REPOSITORIES: biostudies-literature