ANLN functions as a key candidate gene in cervical cancer as determined by integrated bioinformatic analysis.

ABSTRACT:

Background

Cervical cancer, one of the leading causes of female deaths, remains a top cause of mortality in gynecologic oncology and tends to affect younger individuals. However, the pathogenesis of cervical cancer is still far from clear. Given the high incidence and mortality of cervical cancer, uncovering the causes and pathogenesis as well as identifying novel biomarkers are of great significance and are desperately needed.

Materials and methods

First, raw data were downloaded from the Gene Expression Omnibus database. The Robuse Multi-Array Average algorithm and combat function of the sva package were subsequently applied to preprocess and remove batch effects. Differentially expressed genes (DEGs) analyzed with the limma package were followed by gene ontology and pathw

SUBMITTER: Xia L 

PROVIDER: S-EPMC5896649 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature