Dataset Information

Fabrication of ultrasmall WS₂ quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy.

ABSTRACT:

Introduction

The consolidation of different therapies into a single nanoplatform has shown great promise for synergistic tumor treatment. In this study, a multifunctional platform by WS₂ quantum dots (WQDs)-coated doxorubicin (DOX)-loaded periodic mesoporous organosilicas (PMOs-DOX@WQDs) nanoparticles were fabricated for the first time, and which exhibits good potential for synergistic chemo-photothermal therapy.

Materials and methods

The structure, light-mediated drug release behavior, photothermal effect, and synergistic therapeutic efficiency of PMOs-DOX@WQDs to HCT-116 colon cancer cells were investigated. The thioether-bridged PMOs exhibit a high DOX loading capacity of 66.7 μg mg^-1. The gating of the PMOs not only improve the drug loading capacity

SUBMITTER: Liao W

PROVIDER: S-EPMC5896670 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature

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Dataset Information

Fabrication of ultrasmall WS₂ quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy.

Introduction

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Fabrication of ultrasmall WS2 quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy.

Introduction

Materials and methods

OmicsDI is part of the ELIXIR infrastructure

Tweets

Fabrication of ultrasmall WS₂ quantum dots-coated periodic mesoporous organosilica nanoparticles for intracellular drug delivery and synergistic chemo-photothermal therapy.