Evaluation of drug interactions between fimasartan and rosuvastatin after single and multiple doses in healthy Caucasians.

ABSTRACT:

Objectives

As hypercholesterolemia is often accompanied by hypertension, statins are usually prescribed with angiotensin receptor blockers in clinical practice. This study was performed to evaluate the pharmacokinetics and safety of fimasartan and rosuvastatin when coadministered or administered alone as a single dose or as multiple doses to healthy Caucasians.

Methods

Thirty-six subjects were enrolled into an open-labeled, randomized, 6-sequence, 3-period, 3-way crossover study, and randomly received fimasartan (120 mg), rosuvastatin (20 mg) or both. Blood samples for pharmacokinetics were collected up to 48 hours for fimasartan and 72 hours for rosuvastatin after the last dosing and plasma concentrations of study drugs were determined by liquid chromatography-tandem mass s

SUBMITTER: Lee J 

PROVIDER: S-EPMC5896677 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature