Frequency of common polymorphisms in Caveolin 1 ( CAV1 ) gene in adults with high serum triglycerides from Colombian Caribbean Coast.

ABSTRACT:

Background

Caveolin 1 gene (CAV1) has been associated with insulin resistance, metabolic syndrome and hypertension in humans. Also, it has been related to high serum triglycerides in rodents, however there is little evidence of this relation in humans.

Aim

To describe frequencies of common variations in CAV1 in adults with high serum triglycerides.

Methods

A case-control study was carried out with adults from Colombian Caribbean Coast. A whole blood sample was employed to measure serum concentrations of triglycerides, glucose, total cholesterol and HDLc. Six common Single Nucleotide Polymorphism (SNP) in CAV1 were genotyped (rs926198, rs3779512, rs10270569, rs11773845, rs7804372 and rs1049337). Allelic and genotypic frequencies were determined by

SUBMITTER: Mora-Garcia GJ 

PROVIDER: S-EPMC5896723 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature