17-Hydroxyprogesterone caproate in triplet pregnancy: an individual patient data meta-analysis.

ABSTRACT:

Background

Preterm birth complicates almost all triplet pregnancies and no preventive strategy has proven effective.

Objective

To determine, using individual patient data (IPD) meta-analysis, whether the outcome of triplet pregnancy is affected by prophylactic administration of 17-hydroxyprogesterone caproate (17OHPc).

Search strategy

We searched literature databases, trial registries and references in published articles.

Selection criteria

Randomised controlled trials (RCTs) of progestogens versus control that included women with triplet pregnancies.

Data collection and analysis

Investigators from identified RCTs collaborated on the protocol and contributed their IPD. The primary outcome was a composite measure of adverse perinatal outcome. The secondar

SUBMITTER: Combs CA 

PROVIDER: S-EPMC5896762 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature